Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
8
We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
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8
Our study focused on understanding how various forms of selenium can impact prostate cancer, specifically the PC-3 cell line. We utilized a systematic approach called Mixture Design Response Surface Methodology to find the most effective combinations of selenium compounds, including sodium selenite, methylseleninic acid, and nano-selenium.
We began by testing each selenium compound individually to determine their effectiveness at reducing cancer cell viability. Interestingly, we found that the 50:50 mixture of methylseleninic acid and sodium selenite yielded the best results, showcasing impressive antineoplastic potential. However, the combination of nano-selenium with selenite did not demonstrate any additional benefits, suggesting that they might work through similar mechanisms.
This study underscores the importance of recognizing the distinct effects of different selenium compounds when considering them as treatments for prostate cancer. Our findings encourage further research in this area, as the choice and combination of selenium forms could significantly influence treatment outcomes. Overall, selenium shows promise as a potential weapon in the fight against prostate cancer, but we need to keep exploring the variations of these compounds to fully understand their capabilities.
We began by testing each selenium compound individually to determine their effectiveness at reducing cancer cell viability. Interestingly, we found that the 50:50 mixture of methylseleninic acid and sodium selenite yielded the best results, showcasing impressive antineoplastic potential. However, the combination of nano-selenium with selenite did not demonstrate any additional benefits, suggesting that they might work through similar mechanisms.
This study underscores the importance of recognizing the distinct effects of different selenium compounds when considering them as treatments for prostate cancer. Our findings encourage further research in this area, as the choice and combination of selenium forms could significantly influence treatment outcomes. Overall, selenium shows promise as a potential weapon in the fight against prostate cancer, but we need to keep exploring the variations of these compounds to fully understand their capabilities.
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8
We explored how selenium-containing compounds impact prostate cancer, particularly focusing on their potential as both anticancer agents and radical scavengers. In our study, we synthesized a new type of molecule called acylselenourea derivatives, based on structures similar to those found in natural products.
Through various tests, we evaluated these compounds for their ability to fight cancer cells in prostate, colon, lung, and breast cancers, as well as their effectiveness in scavenging free radicals that can damage cells. The results were promising, revealing that some of these new selenium compounds demonstrated strong anticancer activity by inducing cell death through a process known as apoptosis.
Additionally, they showed radical scavenging capability that performed comparably to well-known antioxidants like ascorbic acid and trolox. This suggests that introducing selenium into these small molecules could yield dual benefits, paving the way for future developments in cancer treatment approaches.
Overall, our findings highlight the exciting potential of selenium derivatives in treating prostate cancer and the importance of continued research in this area.
Through various tests, we evaluated these compounds for their ability to fight cancer cells in prostate, colon, lung, and breast cancers, as well as their effectiveness in scavenging free radicals that can damage cells. The results were promising, revealing that some of these new selenium compounds demonstrated strong anticancer activity by inducing cell death through a process known as apoptosis.
Additionally, they showed radical scavenging capability that performed comparably to well-known antioxidants like ascorbic acid and trolox. This suggests that introducing selenium into these small molecules could yield dual benefits, paving the way for future developments in cancer treatment approaches.
Overall, our findings highlight the exciting potential of selenium derivatives in treating prostate cancer and the importance of continued research in this area.
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Most Useful Reviews
6
Increases semen volume
1 people found this helpful
I noticed a significant increase in semen volume when taking it, likely due to enhanced prostate fluid. I recommend it for its antioxidant and detoxifying properties.
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2
No adverse reactions
It worked perfectly without causing any bodily reactions. It combats cancer, although the smell is not very pleasant.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9.5
We aimed to explore how selenium (Se) and zinc (Zn) levels affect the survival of men diagnosed with prostate cancer. In a study conducted in Poland from 2009 to 2015, we enrolled 338 prostate cancer patients and measured their serum levels of these micronutrients before they started any treatment.
By categorizing participants into quartiles based on their Se and Zn levels, we utilized Cox regression to evaluate the relationship between these levels and patient survival. Our findings revealed a notable interaction between selenium and zinc, suggesting that higher combined levels of these micronutrients correlate with increased survival rates in prostate cancer patients.
Specifically, patients in the highest quartile of both Se and Zn showed a remarkably high hazard ratio (HR = 20.9) compared to those in the lowest quartile. However, it’s important to note that while the interaction is significant, our study does not isolate the effects of selenium from zinc alone. Therefore, further research is warranted to better understand optimal selenium and zinc levels for different populations and how they might contribute to prostate cancer outcomes.
By categorizing participants into quartiles based on their Se and Zn levels, we utilized Cox regression to evaluate the relationship between these levels and patient survival. Our findings revealed a notable interaction between selenium and zinc, suggesting that higher combined levels of these micronutrients correlate with increased survival rates in prostate cancer patients.
Specifically, patients in the highest quartile of both Se and Zn showed a remarkably high hazard ratio (HR = 20.9) compared to those in the lowest quartile. However, it’s important to note that while the interaction is significant, our study does not isolate the effects of selenium from zinc alone. Therefore, further research is warranted to better understand optimal selenium and zinc levels for different populations and how they might contribute to prostate cancer outcomes.
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9
We sought to understand how selenium, specifically in the form of lentinan-functionalized selenium nanoparticles (LET-SeNPs), can improve radiotherapy outcomes for prostate cancer. Our investigation showed that when these nanoparticles were combined with X-ray therapy, they significantly hampered the growth of prostate cancer cells and their ability to form colonies. This effect was greater than either treatment alone.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
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9
We explored an innovative approach to treating prostate cancer by developing a unique prodrug that combines a potent HDAC inhibitor with selenium. This new compound, known as SeSA-DCA, was designed to effectively target cancer cells while minimizing side effects.
The study assessed how SeSA-DCA works in the body and its impact on various prostate cancer cell lines. We observed that this compound not only inhibited cancer cell growth but also prompted cell death and reduced metastasis significantly. Our animal studies revealed that SeSA-DCA led to notable tumor shrinkage without causing serious toxicity, outperforming even the standard treatment of docetaxel.
Additionally, we found that SeSA-DCA was stable in the body's environment and broke down rapidly in the tumor area, releasing its active components. This dual-action mechanism makes SeSA-DCA a promising candidate for prostate cancer therapy, potentially improving outcomes for patients while offering a safer alternative to traditional treatments. Overall, our findings suggest that selenium combined with HDAC inhibition can play a crucial role in advancing prostate cancer treatment strategies.
The study assessed how SeSA-DCA works in the body and its impact on various prostate cancer cell lines. We observed that this compound not only inhibited cancer cell growth but also prompted cell death and reduced metastasis significantly. Our animal studies revealed that SeSA-DCA led to notable tumor shrinkage without causing serious toxicity, outperforming even the standard treatment of docetaxel.
Additionally, we found that SeSA-DCA was stable in the body's environment and broke down rapidly in the tumor area, releasing its active components. This dual-action mechanism makes SeSA-DCA a promising candidate for prostate cancer therapy, potentially improving outcomes for patients while offering a safer alternative to traditional treatments. Overall, our findings suggest that selenium combined with HDAC inhibition can play a crucial role in advancing prostate cancer treatment strategies.
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9
We conducted a systematic exploration of natural extracts, with a particular focus on selenium, and its role in managing prostate cancer. The available evidence includes findings from various studies, including our analysis, which assessed the effectiveness of selenium alone and in combination with other extracts, such as silybin.
While selenium was noted in our findings, we found that its effectiveness is not straightforward. Specifically, the interaction between selenium and silybin complicated our ability to isolate the impact of selenium on its own. Thus, it became clear that, although some benefits arise from its combined use, we couldn’t definitively conclude that selenium alone delivers significant advantages for prostate cancer treatment.
Overall, the insights from our network meta-analysis suggest that while silybin and selenium together show promise, we need more studies to establish the detailed benefits and safety of selenium as a standalone treatment for prostate cancer. Those considering natural extract options should proceed with caution, keeping in mind the current limitations in evidence.
While selenium was noted in our findings, we found that its effectiveness is not straightforward. Specifically, the interaction between selenium and silybin complicated our ability to isolate the impact of selenium on its own. Thus, it became clear that, although some benefits arise from its combined use, we couldn’t definitively conclude that selenium alone delivers significant advantages for prostate cancer treatment.
Overall, the insights from our network meta-analysis suggest that while silybin and selenium together show promise, we need more studies to establish the detailed benefits and safety of selenium as a standalone treatment for prostate cancer. Those considering natural extract options should proceed with caution, keeping in mind the current limitations in evidence.
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9
Targeted selenium treatment effective
We investigated how selenium, combined with chemoradiotherapy, could target and treat prostate cancer, specifically in the LNCaP cell line. The study employed a sophisticated design involving methotrexate-selenium nanostructures loaded with Myc decoy oligodeoxynucleotides. This innovative approach aimed to enhance treatment effectiveness when paired with X-irradiation.
Throughout our experiments, we observed that these targeted nanostructures showcased promising characteristics. The selenium nanoparticles displayed a size of around 40 nanometers and a suitable negative charge, indicating a well-structured composite. Notably, they demonstrated hemocompatibility, meaning they are likely safe when interacting with blood cells at lower concentrations.
The results were encouraging: the combination therapy led to significant cell growth inhibition and about 57% apoptosis in the cancer cells. We also noted a substantial cell cycle arrest in the G2/M phase and a migration inhibition of up to 90%. These findings suggest that selenium, when used as part of a carefully designed nanostructure, can enhance the effectiveness of therapies against prostate cancer.
Throughout our experiments, we observed that these targeted nanostructures showcased promising characteristics. The selenium nanoparticles displayed a size of around 40 nanometers and a suitable negative charge, indicating a well-structured composite. Notably, they demonstrated hemocompatibility, meaning they are likely safe when interacting with blood cells at lower concentrations.
The results were encouraging: the combination therapy led to significant cell growth inhibition and about 57% apoptosis in the cancer cells. We also noted a substantial cell cycle arrest in the G2/M phase and a migration inhibition of up to 90%. These findings suggest that selenium, when used as part of a carefully designed nanostructure, can enhance the effectiveness of therapies against prostate cancer.
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User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
6
Increases semen volume
1 people found this helpful
I noticed a significant increase in semen volume when taking it, likely due to enhanced prostate fluid. I recommend it for its antioxidant and detoxifying properties.
Read More
2
No adverse reactions
It worked perfectly without causing any bodily reactions. It combats cancer, although the smell is not very pleasant.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zou Y, Xu H, Wu X, Liu X, Zhao J. Enhancing Radiotherapy Sensitivity in Prostate Cancer with Lentinan-Functionalized Selenium Nanoparticles: Mechanistic Insights and Therapeutic Potential. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16091230
- Sochacka M, Hoser G, Remiszewska M, Suchocki P, Sikora K, et al. Effect of Selol on Tumor Morphology and Biochemical Parameters Associated with Oxidative Stress in a Prostate Tumor-Bearing Mice Model. Nutrients. 2024;16. 10.3390/nu16172860
- Alsulami FJ, Shaheed SU. Role of Natural Antioxidants in Cancer. Cancer Treat Res. 2024;191:95. 10.1007/978-3-031-55622-7_4
- Shi Z, Liu M, Zhang X, Wang J, Zhang J, et al. A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy. Theranostics. 2024;14:3565. 10.7150/thno.92119
- Huang H, Qin J, Wen Z, Liu Y, Chen C, et al. Effects of natural extract interventions in prostate cancer: A systematic review and network meta-analysis. Phytomedicine. 2024;129:155598. 10.1016/j.phymed.2024.155598
- Whitcomb A, Li X, Lawson J, Christensen M. Response surface methodology optimizes selenium inhibition of prostate cancer PC-3 cell viability. J Trace Elem Med Biol. 2024;84:127414. 10.1016/j.jtemb.2024.127414
- Pietrzak S, Marciniak W, Derkacz R, Matuszczak M, Kiljańczyk A, et al. Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients. Nutrients. 2024;16. 10.3390/nu16040527
- Ghorbani R, Gharbavi M, Sharafi A, Rismani E, Rezaeejam H, et al. Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells. Oncol Res. 2023;32:101. 10.32604/or.2023.044741
- Bissardon C, Proux O, Gazze SA, Filhol O, Toubhans B, et al. Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells. Nanomaterials (Basel). 2023;13. 10.3390/nano13232999
- Wei B, Tan W, Wang S, Guo Z, Gan S. Interaction between smoking status and dietary selenium intake affects PSA: A cross-sectional study. Urol Oncol. 2023;41:483.e1. 10.1016/j.urolonc.2023.07.009
- Jiang J, Chen B, Tang B, Wei Q. Selenium in Prostate Cancer: Prevention, Progression, and Treatment. Pharmaceuticals (Basel). 2023;16. 10.3390/ph16091250
- Astrain-Redin N, Raza A, EncÃo I, Sharma AK, Plano D, et al. Novel Acylselenourea Derivatives: Dual Molecules with Anticancer and Radical Scavenging Activity. Antioxidants (Basel). 2023;12. 10.3390/antiox12071331
- Dhillon VS, Deo P, Fenech M. Effect of Selenium and Lycopene on Radiation Sensitivity in Prostate Cancer Patients Relative to Controls. Cancers (Basel). 2023;15. 10.3390/cancers15030979
- Lorenzoni S, Cerra S, Angulo-Elizari E, Salamone TA, Battocchio C, et al. Organoselenium compounds as functionalizing agents for gold nanoparticles in cancer therapy. Colloids Surf B Biointerfaces. 2022;219:112828. 10.1016/j.colsurfb.2022.112828
- Skrajnowska D, Jagielska A, Ruszczyńska A, Idkowiak J, Bobrowska-Korczak B. Effect of Copper and Selenium Supplementation on the Level of Elements in Rats' Femurs under Neoplastic Conditions. Nutrients. 2022;14. 10.3390/nu14061285
- Jin X, Tong W, Sun L, Lu S, Sun P, et al. Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES. Front Immunol. 2025;16:1530174. 10.3389/fimmu.2025.1530174
